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Silicone-based antifoams such as simethicone are widely used in bioprocessing because they are highly effective at controlling foam. For food applications, however, their use introduces an important regulatory consideration: FDA limits dimethylpolysiloxane (PDMS) to 10 parts per million (ppm) in food. Under 21 CFR §173.340, dimethylpolysiloxane may be used as a defoaming agent at no more than 10 ppm in food, except for certain specifically identified applications. The regulat

Cut autoclave prep time to zero while improving sterility and consistency in every batch. Every bioprocess engineer knows the routine. A few hours before inoculation, someone needs to prepare antifoam bottles, label them, run them through the autoclave, and make sure everything cools down in time for use. It sounds simple — but between prep time, steam load, QC release, and the occasional autoclave delay, this small task quietly drains hours of labor and thousands of dollars